Orthostatic hypotension and the risk of incidental cardiovascular diseases: A meta-analysis of prospective cohort studies.
作者： Wei Xin , Shuhua Mi , Zhiqin Lin , Hui Wang , Wei Wei
DOI: 10.1016/J.YPMED.2016.01.007
关键词: Orthostatic vital signs 、 Prospective cohort study 、 Cardiology 、 Meta-analysis 、 Risk assessment 、 Proportional hazards model 、 Hazard ratio 、 Medicine 、 Internal medicine 、 Comorbidity 、 Stroke
摘要: Abstract Objective To quantitatively estimate the prospective associations between orthostatic hypotension (OH) and cardiovascular diseases, including coronary heart disease (CHD) stroke. Methods Relevant cohort studies were identified by searching of Medline Embase databases. We applied fixed or random effect model to overall effects depending on heterogeneity among included studies. Results Eight published articles from 7 cohorts, consisting 64,782 participants, included. During a mean follow-up 15.2 years, 5719 CHD events 3657 stroke occurred. The results meta-analysis indicated that OH was associated with significant increased risk for incident (adjusted hazard ratio [HR]: 1.32, 95% confidence interval [CI]: 1.12–1.56) (HR: 1.19, CI 1.08–1.30), which independent conventional factors. Stratified analyses ages suggested both middle-aged old participants. Conclusion Presence independently related significantly incidence Further, regarding mechanisms potential treatments may be important understanding whether diseases are causative.
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