Expression and Role of the TrkA Receptor in Pulmonary Inflammatory Diseases

摘要: The nerve growth factor NGF belongs to the neurotrophin family and was described for first time more than fifty years ago by Rita Levi-Montalcini collaborators (LeviMontalcini et al., 1995; & Hamburger, 1951), who showed its major role in neuronal survival. effects are mediated activation of two receptor types: low-affinity p75 neurotrophins (p75NTR) high-affinity tropomyosinrelated kinase A (TrkA) (Freund-Michel Frossard, 2008a). p75NTR death at nanomolar concentrations leads either proor anti-apoptotic signalling pathways. is not selective as it can also bind pro-neurotrophins other same (Chao, 2003). Inversely, TrkA tyrosine-kinase family. Its picomolar activates pathways inducing cell proliferation, differentiation survival particular through phosphatidylinositol-3 (PI3K), small protein G Ras, phospholipase C (PLC) mitogen-activated kinases (MAPK) has been widely studied led consider a promising therapeutic target several pathologies nervous system, neurodegenerative diseases (Prakash 2010). In addition, many studies have suggested that plays an inflammatory mediator, lung Indeed, numerous sources lung, including infiltrated cells, sensory nerves, structural cells such fibroblasts, epithelial, endothelial,