Characterization of Leishmania (Leishmania) waltoni n.sp. (Kinetoplastida: Trypanosomatidae), the Parasite Responsible for Diffuse Cutaneous Leishmaniasis in the Dominican Republic
作者： Jeffrey Shaw , Francine Pratlong , Lucile Floeter-Winter , Edna Ishikawa , Fouad El Baidouri
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摘要: Leishmania parasites isolated, between 1979 and 1988 by the late Bryce Walton, from Dominican Republic (DR) patients with diffuse cutaneous leishmaniasis, were characterized using a panel of 12 isoenzymes, 23 monoclonal antibodies, small subunit ribosomal DNA (SSu rDNA), multilocus sequence analysis (MLSA). The isoenzyme antibody profiles MLSA results showed that distinct other described species. This new species belongs to mexicana complex, which is distributed in central parts northern South America. It suggested uniqueness members complex related it being isolated on an island for millions years. If (Leishmania) waltoni fails adapt some imported mammal, such as house rat, will be only classified endangered excessive destruction habitats Hispaniola threatens survival its vectors presumed natural reservoirs, rodent hutias insectivorous mammal solenodon. concept discussed light recent evaluations criteria defining bacterial
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