Human astrocytic bradykinin B2 receptor modulates zymosan-induced cytokine expression in 1321N1 cells
作者： Donghoon Kim , Suk-Hee Cho , Jong-So Kim , Su-Hyun Jo , Sung Joong Lee
DOI: 10.1016/J.PEPTIDES.2009.10.011
关键词:
摘要: Bradykinin is an important modulator of the neurons and glial cells nervous system. secreted from affects astrocytic functions such as neurovascular coupling cytokine production. In human astrocytes, however, detailed mechanism bradykinin-mediated modulation has not yet been fully elucidated. Here, we report functional expression bradykinin B(2) receptor its zymosan-induced in astrocytoma 1321N1 cells. increased cytosolic [Ca(2+)] a concentration-dependent manner, whereas [des-Arg(10)] kallidin (an agonist B(1) receptor) did have this effect. also triggered intracellular InsP(3) Pretreating with HOE140 (icatibant acetate, antagonist) inhibited bradykinin-induced increase contrast, [des-Arg(10)]HOE140 (a show any inhibitory TNF-alpha, interleukin 1beta (IL-1beta) but affect 6 (IL-6) or 10 (IL-10). Interestingly, cyclooxygenase-2 specific inhibitor blocked contrast to result glioma cells, inhibits TNF-alpha IL-1beta rat which shows species-dependent manner. These data suggest that receptors are expressed they modulate pattern inflammatory cytokines.
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