NEW NUCLEOSIDE AND OLIGONUCLEOTIDE ANALOG

摘要: PROBLEM TO BE SOLVED: To obtain a new compound having an intramolecular ether bond and useful for antisense or antigene medicine, primer detecting agent specific gene initiating the amplification intermediate producing primer. SOLUTION: This is represented by formula I R1 R2 are each H, protecting group of OH, (protected)phosphate group, P(R3)R4 [R3 R4 (protected)OH, (protected)amino like]; A 1-4C alkylene; B (substituted)purin-9-yl (substituted)2-oxo-pyrimidin-1-yl), e.g. 5 '-O-dimethoxytrityl -2'-O, 4'-C-ethylene-4 -N -benzoylcytidine-3' -O-(2- cyanoethyl N,N-diisopropyl)phosphoramidite. The produced method, etc., using, II (X Y group) as starting substance, passing through III (R7 capable forming leaving group), providing IV (B1 purin-9-yl like).