A putative integrase gene defines the distal end of a large cluster of ToxR-regulated colonization genes in Vibrio cholerae.
作者： M. E. Kovach , M. D. Shaffer , K. M. Peterson
DOI: 10.1099/13500872-142-8-2165
关键词:
摘要: A large cluster of virulence genes encoding proteins involved in Vibrio cholerae accessory colonization factor (ACF) expression and toxin-coregulated pilus (TCP) biogenesis is flanked by sequences that resemble bacteriophage attachment (att) half-sites. Adjacent to the atfL-like site a gene (int) encodes protein related integrase family site-specific recombinases. The putative vibrio appears be most closely Escherichia coli cryptic prophage (CP4-57) (52% identity, 73% similarity). Genomic analysis numerous V. strains (O1, non-O1 O139) revealed only vibrios capable causing epidemic Asiatic cholera possess TCP-ACF association with integrase. fact absent avirulent suggests obtained via horizontal transfer.
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