LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling
作者： Shurui Ouyang , Xinbin Zheng , Xin Zhou , Zhengquan Chen , Xuefeng Yang
DOI: 10.18632/ONCOTARGET.21590
关键词:
摘要: // Shurui Ouyang 1 , Xinbin Zheng Xin Zhou Zhengquan Chen Xuefeng Yang and Ming Xie Gastrointestinal Department, Affiliated Hospital of Zunyi Medical College, Guizhou 563000, China Correspondence to: Xie, email: wanqiuniao@126.com Keywords: BCAR4, colon cancer, proliferation, Wnt/β-catenin Received: August 01, 2017 Accepted: September 04, Published: October 06, 2017 ABSTRACT BCAR4 (Breast Cancer Anti-Estrogen Resistance 4) is a long noncoding RNA that was identified as an oncogene in breast cancer. In our research, we found the expression level upregulated cancer tissues compared to paired normal tissues. What’s more, higher correlated with lower survival rate patients Mechanistically, showed activated signaling by protecting β-catenin from degradation. We also overexpression promoted cell proliferation migration However, silencing inhibited growth apoptosis. Besides, knockdown decreased tumor vivo . These findings indicate facilitated progression enhancing inhibiting apoptosis via BCAR4/β-catenin axis. may be useful new target for treatment
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