Stem cell guidance through the mechanistic target of rapamycin.

摘要: Stem cells offer great promise for the treatment of multiple disorders throughout body. Critical to this premise is ability govern stem cell pluripotency, proliferation, and differentiation. The mechanistic target rapamycin (mTOR), 289-kDa serine/threonine protein kinase, that a vital component mTOR Complex 1 2 represents critical pathway oversight maintenance. can control programmed death pathways autophagy apoptosis yield variable outcomes in survival be reliant upon proliferative include Wnt signaling, Wnt1 inducible signaling (WISP1), silent mating type information regulation homolog (Saccharomyces cerevisiae) (SIRT1), trophic factors. also necessary early development establishment as well having significant impact maturation specific phenotypes. Yet, agent, not only foster cancer tumorigenesis, but mediate senescence under certain conditions limit invasive growth. offers an exciting therapies requires careful consideration diverse clinical fueled by pathways.