Bacterial remodelling of the host epigenome: functional role and evolution of effectors methylating host histones

摘要: The modulation of the chromatin organization eukaryotic cells plays an important role in regulating key cellular processes including host defence mechanisms against pathogens. Thus, to successfully survive a cell, sophisticated bacterial strategy is subversion nuclear cell. Indeed, number proteins that target remodel epigenetic machinery expanding. Some identified effectors are 'eukaryotic-like' as they mimic histone writers carrying same enzymatic activities. best-studied examples SET domain methylate histones change landscape. In this review, we will discuss Legionella, Chlamydia and Bacillus genomes encode activities targeting histones. Moreover, their possible origin having evolved from prokaryotic ancestors or been acquired hosts during co-evolution. characterization such modifiers landscape exciting field research it elucidates new strategies not only manipulate functions through modifications but may also identify mammalian known before.