Anthrax SET Protein

摘要: Abstract Toxins play a major role in the pathogenesis of Bacillus anthracis by subverting host defenses. However, besides toxins, B. expresses effector proteins, whose are yet to be investigated. Here we present that suppressor-of-variegation, enhancer-of-zeste, trithorax protein from (BaSET) methylates human histone H1, resulting repression NF-κB functions. Notably, BaSET is secreted and undergoes nuclear translocation enhance H1 methylation anthracis-infected macrophages. Compared with wild type Sterne, delayed growth kinetics altered septum formation were observed knock-out (BaΔSET) bacilli. Uncontrolled expression during complementation gene BaΔSET partially restored stationary phase but resulted substantially shorter bacilli throughout cycle. Importantly, contrast avirulent lethal murine bacteremia model infection. Collectively, required for transcription as well proper growth, making it potentially unique virulence determinant.