Biology of Primitive Neuroectodermal Tumors

摘要: As a group, brain tumors are the most common to occur in children. Primitive neuroectodermal is designation widely used clinically identify family of undifferentiated embryonal neuroepithelial origin. This group recognized as including medulloblastoma, supratentorial primitive tumors, and atypical teratoid/rhabdoid tumors. A variety classification efforts, some described this chapter, have sought classify these Initially, they were grouped together simply on basis their histologic appearance, which did not reflect specific cellular lineages. The morphology mimicked appearance cells found largely only during embryonic development. Subsequent attempted include evaluation more precise estimates origin, pathology, genetic alterations that contributed recent World Health Organization (WHO) nervous system based upon individual tumor entities, but describes molecular characteristics entities name where such information exists (79). includes tissue, also less commonly occurring medulloepithe-lioma ependymoblastoma.