Regulation of IgM anti-bovine γ-globulin antibody formation by helper and suppressor T cells in rabbits

摘要: Abstract Primary IgM anti-bovine γ-globulin (BGG) antibody formation was studied in rabbits subjected to 500 or 900 R of whole body X-irradiation combination with one more the following conditions: appendectomy (Ax), thymectomy (Tx), shielding appendix (As) bone marrow (Bs) during irradiation (X), transfer 10 9 thymus cells (Ac Tc), and immediate immunization 200 μg alum-precipitated BGG iv. The response well preserved AsX comparison X rabbits. Conversely, suppressed AxX although autologous these animals (AxX .Ac) restored response. In group receiving R, there variable restoration individual AxX.Ac AxBsX.Ac little none AxTxX.Tc, AxTxBsX.Tc, AxTxBsX.Ac animals. However, simultaneous injections lymphocytes (AxTxX.Ac.Tc) completely. somewhat enhanced AsTxX returned again level normal controls by injecting cells. marked suppression seen when were injected neonatal allogeneic A remarkable enhancement induced injection PHA into appendiceal artery. On basis results histological observations, it suggested that rabbit represents a large pool both B T appendix-derived participating anti-BGG are under regulation helper suppressor