Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung.

摘要: Development of a new drug for the treatment lung disease is complex and time consuming process involving numerous disciplines basic applied sciences. During 2015 Congress International Society Aerosols in Medicine, group experts including aerosol scientists, physiologists, modelers, imagers, clinicians participated workshop aiming at bridging gap between research clinical efficacy inhaled drugs. This publication summarizes current consensus on topic. It begins with short description concepts transport discussion targeting strategies aerosols to lungs. followed by both computational biological models, use imaging techniques determine deposition distribution (ADD) lung. Finally, importance ADD discussed. Several gaps were identified science efficacy. One scientific aimed predicting, controlling, measuring considerable challenge obtaining, single study, accurate information describing optimal regions be targeted, effectiveness determined from ADD, some measure drug's effectiveness. Other language methodology barriers that exist among disciplines, along significant regulatory hurdles need overcome novel drugs and/or therapies reach marketplace benefit patient. Despite these gaps, much progress has been made recent years improve Also, efforts many funding agencies industry support multidisciplinary networks researchers, R&D will go long way further reduce