Micron-sized and submicron-sized aerosol deposition in a new ex vivo preclinical model

摘要: The knowledge of where particles deposit in the respiratory tract is crucial for understanding health effects associated with inhaled drug particles. An ex vivo study was conducted to assess regional deposition patterns (thoracic vs. extrathoracic) radioactive polydisperse aerosols different size ranges [0.15 μm–0.5 μm], [0.25 μm–1 μm] and [1 μm–9 μm]. SPECT/CT analyses were performed complementary order more precisely within pulmonary tract. Experiments set using an original model composed a human plastinated head connected porcine ventilated by passive expansion, simulating pleural depressions. Aerosol administered during nasal breathing. Planar scintigraphies allowed calculate deposited aerosol fractions three from sub-micron micron obtained, thoracic extra-thoracic regions respectively, 89 ± 4 % 11 ± 4 % 78 ± 5 % 22 ± 5 % 35 ± 11 % vs.65 ± 11 % Results obtained this new are good agreement data studies baboons humans.