Effect of Posture on Regional Deposition of Coarse Particles in the Healthy Human Lung.

摘要: Abstract Background: Understanding the regional partition of deposition inhaled particles within lung is important for improving targeted delivery aerosolized drugs. One factor affecting gravity. As deforms under its own weight, changes in volume, airway geometries, and spatial patterns ventilation distribution between postures have potential to alter deposited particles. Methods: Using gamma-scintigraphy, we measured clearance 99mTc labeled (5 μm) 6 healthy subjects, with aerosol inhalation occurring both supine seated at constant flow (0.5 L/sec) breathing rate (15 breaths/min). After deposition, mucociliary data were collected posture, immediately post-particle administration, 1 h 30 min, 4 h, 22 h post-inhalation. Relative was computed using retention (R) different time points, wit...