Layer 4 Pyramidal Neurons Exhibit Robust Dendritic Spine Plasticity In Vivo after Input Deprivation

作者: Amaya Miquelajauregui , Sahana Kribakaran , Ricardo Mostany , Aurora Badaloni , G Giacomo Consalez

DOI: 10.1523/JNEUROSCI.5215-14.2015

关键词:

摘要: Pyramidal neurons in layers 2/3 and 5 of primary somatosensory cortex (S1) exhibit somewhat modest synaptic plasticity after whisker input deprivation. Whether involved at earlier steps sensory processing show more or less has not yet been examined. Here, we used longitudinal vivo two-photon microscopy to investigate dendritic spine dynamics apical tufts GFP-expressing layer 4 (L4) pyramidal the vibrissal (barrel) S1 unilateral trimming. First, characterize molecular, anatomical, electrophysiological properties identified L4 Ebf2-Cre transgenic mice. Next, that deprivation results a substantial (∼50%) increase rate loss, acutely (4–8 d) This robust suggests thalamic recipient may be particularly sensitive changes experience. mice thus provide useful tool for future assessment initial S1.

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