Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals.

作者: Mark R. Miller , Stephen J. Borthwick , Catherine A. Shaw , Steven G. McLean , Daniel McClure

DOI: 10.1289/EHP.0800235

关键词:

摘要: BackgroundDiesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects air pollution.ObjectivesWe assessed in vitro DEP on vascular function, nitric oxi...

参考文章(62)
James N. Bates, Max T. Baker, Ricardo Guerra, David G. Harrison, Nitric oxide generation from nitroprusside by vascular tissue Biochemical Pharmacology. ,vol. 42, pp. S157- S165 ,(1991) , 10.1016/0006-2952(91)90406-U
H L Fung, E A Kowaluk, P Seth, Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. Journal of Pharmacology and Experimental Therapeutics. ,vol. 262, pp. 916- 922 ,(1992)
J. Timothy Dvonch, Robert D. Brook, Gerald J. Keeler, Sanjay Rajagopalan, Louis G. D'Alecy, Frank J. Marsik, Masako Morishita, Fuyuen Y. Yip, Jeffrey R. Brook, Edward J. Timm, James G. Wagner, Jack R. Harkema, Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginine. Inhalation Toxicology. ,vol. 16, pp. 473- 480 ,(2004) , 10.1080/08958370490439678
Emiko Muto, Toshio Hayashi, Kazuyoshi Yamada, Teiji Esaki, Masaru Sagai, Akihisa Iguchi, Endothelial-constitutive nitric oxide synthase exists in airways and diesel exhaust particles inhibit the effect of nitric oxide. Life Sciences. ,vol. 59, pp. 1563- 1570 ,(1996) , 10.1016/0024-3205(96)00487-0
V. Chauhan, D. Breznan, P. Goegan, D. Nadeau, S. Karthikeyan, J.R. Brook, R. Vincent, Effects of ambient air particles on nitric oxide production in macrophage cell lines Cell Biology and Toxicology. ,vol. 20, pp. 221- 239 ,(2004) , 10.1023/B:CBTO.0000038461.02222.95
Yoshinobu Saito, Arata Azuma, Shoji Kudo, Hajime Takizawa, Isamu Sugawara, LONG-TERM INHALATION OF DIESEL EXHAUST AFFECTS CYTOKINE EXPRESSION IN MURINE LUNG TISSUES: COMPARISON BETWEEN LOW- AND HIGH-DOSE DIESEL EXHAUST EXPOSURE Experimental Lung Research. ,vol. 28, pp. 493- 506 ,(2002) , 10.1080/01902140290096764
Nino Künzli, Michael Jerrett, Wendy J. Mack, Bernardo Beckerman, Laurie LaBree, Frank Gilliland, Duncan Thomas, John Peters, Howard N. Hodis, Ambient air pollution and atherosclerosis in Los Angeles. Environmental Health Perspectives. ,vol. 113, pp. 201- 206 ,(2004) , 10.1289/EHP.7523
Chris M. Maragos, Deborah Morley, David A. Wink, Tambra M. Dunams, Joseph E. Saavedra, Aaron Hoffman, Alfred A. Bove, Lawrence Isaac, Joseph A. Hrabie, Larry K. Keefer, Complexes of 'NO with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide. Vasorelaxant Effects Journal of Medicinal Chemistry. ,vol. 34, pp. 3242- 3247 ,(1991) , 10.1021/JM00115A013
Zhuowei Li, Jacqueline D. Carter, Lisa A. Dailey, Yuh-Chin T. Huang, Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor. Environmental Health Perspectives. ,vol. 113, pp. 1009- 1014 ,(2005) , 10.1289/EHP.7736