Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis

作者: Frank Stappenbeck , Michael E. Jung , Farhad Parhami

DOI:

关键词:

摘要: This invention relates, e.g., to a synthetic compound, Oxy133, having the structure [Formula I] or bioactive pharmaceutical composition comprising Oxy133 and pharmaceutically acceptable carrier. Methods are also disclosed for using compound treat variety of disorders, including e.g. bone obesity, cardiovascular neurological disorders.

参考文章(343)
Ryszard Galus, Paweł Włodarski, Krzysztof H Włodarski, Fluvastatin does not elevate periosteal osteogenesis induce by Moloney sarcoma virus (MSV) in mice. Pharmacological Reports. ,vol. 58, pp. 60- 66 ,(2006)
Uskokovic Milan Radoje, Narwid Thomas Albert, Iacobelli Jerome Anthony, Synthesis of 1{60 -hydroxylated cholesterol derivatives ,(1973)
Valeria Marigo, Clifford Tabin, Andrew P. McMahon, Philip W. Ingham, Screening assays for agonists and antagonists of the hedgehog signaling pathway ,(2000)
Arnold I. Caplan, The Mesengenic Process Clinics in Plastic Surgery. ,vol. 21, pp. 429- 435 ,(1994) , 10.1016/S0094-1298(20)31020-8
Alain Brzokewicz, Jean-Claude Caron, Braham Villa Shroot, Danièle Caron, Complexes from anthralin and one sterol, process for their preparation and their use in therapeutics and cosmetics ,(1989)