Fluvastatin does not elevate periosteal osteogenesis induce by Moloney sarcoma virus (MSV) in mice.

摘要: Several studies have demonstrated the pleiotropic effects of statins. Since Wang and associates reported that in rabbits lovastatin reduced steroid-induced bone loss, numerous authors confirmed these data, however, others conflicting results. In this study, fluvastatin on formation were investigated early late phase osteogenesis. first set experiments (early osteogenesis) CFW/L1 mice randomly divided into three groups. Two groups injected with Moloney-murine sarcoma virus (Mo-MSV) right thighs to induce orthotopic formation. Mice experimental group received for 11 consecutive days. Thirty days after Mo-MSV inoculation, total serum cholesterol, triglycerides, high- low-density lipoprotein alkaline phosphatase (AP) measured mineral increase was calculated. second (late osteogenesis), administered from day inoculation 20 Fluvastatin administration osteogenesis made no significant difference average compared receiving placebo. Lipid profile AP not significantly affected. During osteogenesis, femural dry mass lower than control group. Also, Mo-MSV-initiated tumors disappeared earlier treated fluvastatin. This may be attributed antioncogenic potential These results also point out at sites seems a useful model examine