Ambient carbon monoxide exposure and elevated risk of mortality in the glioblastoma patients: A double-cohort retrospective observational study.

摘要: An increasing number of studies indicate air pollutants infiltrate into the brain. We aimed to find association cumulative pollution exposure in main body primary brain tumor: glioblastoma (GBM). In this double-cohort, retrospective analysis study with a protocol, we compared health effect on GBM patients from SEER (Surveillance, Epidemiology, and End Results Program) 27 U.S. counties 10 states Severance cohort Korea. From 2000 2015, 10621 were individually evaluated for average each pollutant, 9444 (88.9%) mortality events reported. 2011 2018, 398 same protocol showed 259 (65.1%) events. The multi-pollutant models show that level risk CO is increased (HR 1.252; 95% CI 1.141-1.373) an linear trend relative death rate spline curve. data such statistically significant result impact patients. overall survival gain less group against was 2 3 months two cohorts. Perioperative may increase shorter cohort.