Iron Proteins with Mononuclear Active Sites
作者： Joseph P. Emerson , Mark P. Mehn , Lawrence Que
DOI: 10.1002/9781119951438.EIBC0106
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摘要: Metalloenzymes containing a mononuclear nonheme iron center are often involved in dioxygen metabolism. We have divided this superfamily of enzymes into seven subcategories: superoxide dismutase and reductase, lipoxygenase, catechol dioxygenases, α-keto acid-dependent enzymes, isopenicillin N synthase, pterin-dependent hydroxylases, Rieske dioxygenases. The degree catalytic versatility coordination flexibility encompassed by these is unsurpassed any other known metalloenzyme superfamily. Herein we discuss the present state knowledge regarding their active site structures critical role metal plays respective mechanisms. Keywords: dioxygen; superoxide; lipoxygenase; dioxygenase; monooxygenase; extradiol; intradiol; pterin; Rieske; 2-oxoglutarate; model complexes
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