The pharmacology of verapamil. I. Elimination kinetics in dogs and correlation of plasma levels with effect on the eletrocardiogram.

摘要: The elimination kinetics of verapamil, an experimental antiarrhythmic agent which inhibits slow-channel activity, have been studied in mongrel dogs after i.v. drug administration. disposition verapamil follows first-order and may be adequately described by a one-compartment model. After single doses the drug, overall rate constant (mean +/-S.E.M.) was 0.0146 +/- 0.0021 min-1; apparent volume distribution 4.47 0.40 liters/kg; total body clearance 1244 113.4 ml/min. longer infusions, were similar to those found with bolus dosing. A linear relationship between plasma concentrations changes atrioventricular conduction time, as estimated from P-R interval surface electrocardiogram (r = 0.95, P less than .001). No seen QRS duration Q-T interval. These data show that effect on slow-channel-dependent heart is directly related concentration plasma.