Pharmacokinetics of verapamil: Experience with a sustained intravenous infusion regimen☆

摘要: Disappearance kinetic characteristics of verapamil were determined in 9 patients after a single intravenous dose. From the pharmacokinetic variables determined, we designed an regimen to maintain plasma concentration 150 ng/ml consisting (1) loading bolus (10 mg over 2 minutes), followed by (2) rapid infusion (0.375 mg/min) for 30 minutes, and finally (3) maintenance (0.125 mg/min). We tested this 7 12 hours, found it be safe produce stable prolongation P-R interval. Verapamil was highest immediately administration prevented from falling below 67 infusion. Maintenance remained between 77 156 all patients, averaged 122 ng/ml. Transient slight decreases brachial blood pressure sinus cycle length occurred coincident with maximum concentration. Maximum lagged behind peak but sustained duration Prolongation interval not significantly different at end that 90 minutes start regimen. No patient demonstrated significant side effects, arrhythmia, or clinically important hypotension. Although specified produced final averaging 125 ng/ml, is predicted regimens producing other concentrations can similarly devised changing bolus, infusion, doses proportion desired