Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma.
作者： Emma L. Heeley , Jens M. Hohlfeld , Norbert Krug , Anthony D. Postle
DOI: 10.1152/AJPLUNG.2000.278.2.L305
关键词:
摘要: Electrospray ionization mass spectrometry was used to quantify phosphatidylcholine (PC) and phosphatidylglycerol (PG) molecular species in bronchoalveolar lavage fluid (BALF) from control mild asthmatic subjects after local allergen challenge. BALF obtained 5 13 before 24 h segmental saline There were no differences the ratio of total PC PG or composition between groups under basal conditions. Allergen challenge but not volunteers caused a significant increase PC-to-PG because increased concentrations containing linoleic acid (16:0/18:2 PC, 18:0/18:2 18:1/18:2 PC). These characteristic plasma analyzed same subjects, strongly suggesting that altered due infiltration lipoprotein, catabolism surfactant phospholipid. Interactions lipoprotein infiltrate may contribute dysfunction potentiate disease severity asthma.
sci-hub.se 参考文章(23)
A Szczeklik, Romain Pauwels, R Dahl, D Evans, R Rodriguezroisin, Sotes, Ww Busse, Fe Hargreave, Tjh Clark, Partridge, Sears, Al Sheffer, A Rubinfeld, St Holgate, Lm Fabbri, H Magnussen, J Warner, J Bousquet, INTERNATIONAL CONSENSUS REPORT ON DIAGNOSIS AND TREATMENT OF ASTHMA. European Respiratory Journal. ,vol. 5, pp. 601- 641 ,(1992)
Fujimura M, Ogawa H, Matsuda T, Kurashima K, Kobayashi T, Ohka T, A pilot study of surfactant inhalation in the treatment of asthmatic attack. Arerugī (Allergy). ,vol. 40, pp. 160- ,(1991)
Grant R. Bartlett, Phosphorus Assay in Column Chromatography Journal of Biological Chemistry. ,vol. 234, pp. 466- 468 ,(1959) , 10.1016/S0021-9258(18)70226-3
Goran Enhorning, Pulmonary surfactant function in alveoli and conducting airways Canadian Respiratory Journal. ,vol. 3, pp. 21- 27 ,(1996) , 10.1155/1996/364751
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
D. Yager, J. P. Butler, J. Bastacky, E. Israel, G. Smith, J. M. Drazen, Amplification of airway constriction due to liquid filling of airway interstices. Journal of Applied Physiology. ,vol. 66, pp. 2873- 2884 ,(1989) , 10.1152/JAPPL.1989.66.6.2873
Nikolas A. Vrettos, Hironobu Imakoma, Morio Okazaki, An effective medium treatment of the transport properties of a Voronoi tesselated network Journal of Applied Physics. ,vol. 66, pp. 2873- 2878 ,(1989) , 10.1063/1.344192
Xianlin Han, Richard W. Gross, Structural determination of picomole amounts of phospholipids via electrospray ionization tandem mass spectrometry. Journal of the American Society for Mass Spectrometry. ,vol. 6, pp. 1202- 1210 ,(1995) , 10.1016/1044-0305(95)00568-4
M. LIU, L. WANG, G. ENHORNING, Surfactant dysfunction develops when the immunized guinea-pig is challenged with ovalbumin aerosol Clinical & Experimental Allergy. ,vol. 25, pp. 1053- 1060 ,(1995) , 10.1111/J.1365-2222.1995.TB03251.X
K Kurashima, M Fujimura, T Matsuda, T Kobayashi, Surface activity of sputum from acute asthmatic patients. American Journal of Respiratory and Critical Care Medicine. ,vol. 155, pp. 1254- 1259 ,(1997) , 10.1164/AJRCCM.155.4.9105063