Primary sclerosing cholangitis leads to dysfunction and loss of MAIT cells.

摘要: Primary sclerosing cholangitis (PSC) is a severe chronic liver disease of the small and large bile ducts. The pathogenesis unknown but strong immune cell component has been suggested. Mucosal-associated invariant T (MAIT) cells are abundant in human localize around Yet, role MAIT PSC remains unclear. Here, we performed detailed characterization circulation assessed their presence ducts patients as well non-PSC controls. We observed dramatic reduction levels patients. High-dimensional phenotypical analysis using stochastic neighbor embedding revealed to be activated, phenotype shared by investigated control groups. In line with noted phenotypic alterations, function was reduced response Escherichia coli cytokine stimulation compared healthy Using novel sampling approach ducts, found specifically enriched within Finally, distinct from decline circulation, PSC-patients had retained Altogether, our results provide insight into how compartment affected PSC.