Cost-effectiveness of recombinant human hyaluronidase-facilitated subcutaneous versus intravenous rehydration in children with mild to moderate dehydration

摘要: Abstract Objective To evaluate the cost-effectiveness of recombinant human hyaluronidase–facilitated subcutaneous (rHFSC) fluid administration compared to intravenous (IV) in children with mild moderate dehydration emergency department (ED). Methods A decision analytic model was created based on results a controlled clinical trial that isotonic fluids via rHFSC or IV for rehydration. The costs were determined from hospital’s perspective. effectiveness unit successful rehydration ED without need hospitalization continued hydration. Mean estimates both cost and each treatment. incremental differences between treatments. Sensitivity analysis testing also conducted. Results treatment success rate 93% 76% fluids. Across all ages, mean $722, $889 difference due larger number patients whom access could not be established, necessitating rescue route deliver parenteral overall primarily shorter time receiving versus those treated most apparent younger ( Conclusion Analysis this data revealed demonstrated greater than traditional ED. primary reasons ease obtaining young (especially under 3) where is difficult, stay administration.