Myelin Proteolipid Protein Forms a Complex with Integrins and May Participate in Integrin Receptor Signaling in Oligodendrocytes
作者： Tatyana I. Gudz , Tracy E. Schneider , Thomas A. Haas , Wendy B. Macklin
DOI: 10.1523/JNEUROSCI.22-17-07398.2002
关键词:
摘要: Myelination of axons in the CNS by oligodendrocytes is a process critical to rapid and efficient impulse conduction. A new role for myelin proteolipid protein (PLP), most abundant myelin, has been identified, studies showing PLP interaction with signaling proteins oligodendrocytes. In particular, these suggest that may be involved through integrins Stimulation muscarinic acetylcholine receptors on induced formation tripartite complex containing PLP, calreticulin, alpha(v)-integrin. interacted directly cytoplasmic domain Complex was mediated phospholipase C Ca2+ binding high affinity site calreticulin. This appears important fibronectin These data establish novel function as part integrin neurotransmitter-mediated receptor myelinogenesis.
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