Lysosomal enzyme release in the isolated perfused heart of immunized rats.
作者： M FIELDS , A LAUFER
DOI: 10.1016/S0022-2828(77)80013-8
关键词:
摘要: The present study reports alterations in lysosomal enzymes the rat myocardium and effuent perfusate, following immunization with homologous heart homogenates Freund's adjuvant, records effect of isoproterenol on enzyme release, employing isolated perfused hearts. Pathological findings were found treated animals or without prior immunization. A selective release was observed all groups animals. Immunization alone decreased activity cathepsin D but increased its effluent perfusate. Although myocardial acid phosphatase experimental animals, this not released into It is suggested that cause after may be due to membrane permeability. Isoproterenol β-glucuronidase tissue, only Some above also encountered No correlation between perfusate extent damage.
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