alpha-spectrin is required for germline cell division and differentiation in the Drosophila ovary

作者: A.C. Spradling , M. de Cuevas , J.K. Lee

DOI: 10.1242/DEV.122.12.3959

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摘要: During Drosophila oogenesis, developing germline cysts are spanned by a large cytoplasmic structure called a fusome, containing alpha-spectrin and the adducin-like product of the hu-li tai shao (hts) gene. We found that fusomes contain two additional membrane skeletal proteins: beta-spectrin and ankyrin. hts was shown previously to be required for cyst formation and oocyte differentiation; the role of the fusome itself, however, and the organization and function of its other components, remains unclear. Using the …

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