Applications of Recombinant Dna Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part B: Eukaryotic Gene Transcription and Post-Transcripional Rna Processing

摘要: The transcription of DNA into RNA is the primary level at which gene expression controlled in eukaryotic cells. Eukaryotic  involves several different polymerases that interact with a host factors to initiate transcription. Genes encode proteins are transcribed messenger (mRNA) by polymerase II. Ribosomal RNAs (rRNAs) and transfer (tRNAs) I III, respectively.  The production each mRNA human cells involves complex interactions (ie, trans-acting factors) specific sequences on cis-acting elements). Cis-acting elements short base adjacent or within particular gene. While regulation pivotal step control expression, variety molecular events, collectively known as ’RNA processing’  add an additional