Applications of recombinant DNA technology in gastrointestinal medicine and hepatology: basic paradigms of molecular cell biology. Part C: protein synthesis and post-translational processing in eukaryotic cells.

摘要: The translation of mRNA constitutes the first step in synthesis a functional protein. polypeptide chain is subsequently folded into appropriate three-dimensional configuration and undergoes variety processing steps before being converted its active form. These are intimately related to cellular events that occur endoplasmic reticulum Golgi compartments, determine sorting transport different proteins their destinations within cell. While regulation gene expression occurs primarily at level transcription, many genes can also be controlled translation. Most regulated response extracellular signals. In addition, intracellular protein levels by differential rates degradation. Thus, both amounts activities ultimately determines all aspects cell behaviour.