Trajectories of growth among children who have coronary events as adults.

摘要: BACKGROUND Low birth weight is a risk factor for coronary heart disease. It uncertain how postnatal growth affects disease risk. METHODS We studied 8760 people born in Helsinki from 1934 through 1944. Childhood had been recorded. A total of 357 men and 87 women admitted to the hospital with or died Coronary factors were measured subset 2003 people. RESULTS The mean body size children who events as adults was below average at birth. At two years age thin; subsequently, their body-mass index (BMI) increased relative that other reached values by 11 age. In simultaneous regressions, hazard ratios associated 1 SD increase BMI 0.76 (95 percent confidence interval, 0.66 0.87; P<0.001) 2 1.14 1.00 1.31; P=0.05) among boys. corresponding figures girls 0.62 0.46 0.82; P=0.001) 1.35 1.02 1.78; P=0.04). also raised fasting insulin concentrations (P<0.001 both). CONCLUSIONS On average, event small thin thereafter put on rapidly. This pattern during childhood resistance later life. more strongly related tempo gain than attained any particular