Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo

摘要: Background Epithelial cell (EC)-derived Interleukin-7 (IL-7) plays a crucial role in control of neighboring intestinal intraepithelial lymphocytes (IEL) development and homeostasis, IEL derived keratinocyte growth factor (KGF) promotes epithelial growth, which was regulated by EC-derived IL-7. On this basis, we hypothesize that there is crosstalk between IELs ECs, KGF could regulate the IL-7 expression, should be associated with protective effects on injury.