Effects of intraepithelial lymphocyte-derived cytokines on intestinal mucosal barrier function.
作者： Yuan Qiu , Hua Yang
关键词:
摘要: The mucosal surface of the gastrointestinal tract directly interacts with lumen, which is continuously exposed to foreign antigens. Specialized intraepithelial lymphocytes (IELs), located between basolateral surfaces epithelial cells, are important as first line defense against microbes well for their role in maintenance barrier homeostasis. Although IELs mainly composed T they phenotypically and functionally distinct from cells peripheral blood or spleen. Not only stimulated by antigens intestinal lumen but also regulatory immune cells. integrity closely tied IEL function. Cytokines produced modulate cellular functions that trigger downstream signaling pathways mediate In this review, we will address broad spectrum cytokines derived functional regulation ...
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