The effect of maternal milk on neonatal morbidity of very low-birth-weight infants.

作者: Lydia Furman , Gerry Taylor , Nori Minich , Maureen Hack

DOI: 10.1001/ARCHPEDI.157.1.66

关键词:

摘要: Objective To examine the dose effect of maternal milk on neonatal morbidity very low-birth-weight ( Design Prospective observational study. Setting An urban tertiary care intensive unit and follow-up clinic. Population One hundred nineteen singleton infants admitted from January 1, 1997, to February 14, 1999 (mean birth weight, 1056 g; mean gestational age, 28 weeks; 57% male; 43% white). Methods A comparison outcomes daily graded doses (1-24, 25-49, ≥50 mL/kg body weight) through week 4 life vs a reference group receiving no milk. Main Outcome Measures Neonatal examined included rates sepsis after age 5 days, retinopathy prematurity, chronic lung disease, necrotizing enterocolitis, jaundice, duration ventilator dependence, length hospital stay. Results Seventy-nine (66%) received milk, whom 32 at least 50 per day life. Poisson regression analysis adjusting for sex, ethnicity revealed that number episodes was lower by factor 0.27 (95% confidence interval, 0.08-0.95) compared with There other outcomes. Conclusions threshold amount is needed decrease rate in infants, but does not affect morbidities.

参考文章(29)
Marie C. McCormick, Donald A. Goldmann, Douglas K. Richardson, James E. Gray, Kathryn Workman, Score for neonatal acute physiology : a physiologic severity index for neonatal intensive care Pediatrics. ,vol. 91, pp. 617- 623 ,(1993)
G. Gole, E. Palmer, G. Quinn, I. Ben-Sira, A. Rosenbaum, I. Nissenkorn, A. Deutman, A. Mccormick, F. Koerner, D. Stark, K. Tan, Y. Tanaka, A. Majima, J. Flynn, D. Schaffer, N. W. Hindle, H. Ideta, J. Kingham, H. Fledelius, A. Mushin, W. Konen, B. Svedbergh, A. Garner, An international classification of retinopathy of prematurity Pediatrics. ,vol. 74, pp. 127- 133 ,(1984)
Andrew T Shennan, Michael S Dunn, Ame Ohlsson, Kathryn Lennox, Elizabeth M Hoskins, None, Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics. ,vol. 82, pp. 527- 532 ,(1988)
V. Y. H. YU, J. JAMIESON, B. BAJUK, Breast milk feeding in very low birthweight infants. Journal of Paediatrics and Child Health. ,vol. 17, pp. 186- 190 ,(1981) , 10.1111/J.1440-1754.1981.TB01936.X
Margit Hamosh, Bioactive factors in human milk. Pediatric Clinics of North America. ,vol. 48, pp. 69- 86 ,(2001) , 10.1016/S0031-3955(05)70286-8
A Powls, N Botting, R W Cooke, D Pilling, N Marlow, Growth impairment in very low birthweight children at 12 years: correlation with perinatal and outcome variables. Archives of Disease in Childhood-fetal and Neonatal Edition. ,vol. 75, ,(1996) , 10.1136/FN.75.3.F152
Indira Narayanan, Shashi Bala, K. Prakash, R.K. Verma, V.V. Gujral, PARTIAL SUPPLEMENTATION WITH EXPRESSED BREAST-MILK FOR PREVENTION OF INFECTION IN LOW-BIRTH-WEIGHT INFANTS The Lancet. ,vol. 316, pp. 561- 563 ,(1980) , 10.1016/S0140-6736(80)91994-7
Barbara J. Stoll, Tavia Gordon, Sheldon B. Korones, Seetha Shankaran, Jon E. Tyson, Charles R. Bauer, Avroy A. Fanaroff, James A. Lemons, Edward F. Donovan, William Oh, David K. Stevenson, Richard A. Ehrenkranz, Lu-Ann Papile, Joel Verter, Linda L. Wright, Early-onset sepsis in very low birth weight neonates : A report from the National Institute of Child Health and Human Development Neonatal Research Network The Journal of Pediatrics. ,vol. 129, pp. 72- 80 ,(1996) , 10.1016/S0022-3476(96)70191-9
A. S. GOLDMAN, L. W. THORPE, R. M. GOLDBLUM, L. A. HANSON, Anti-inflammatory properties of human milk. Acta Paediatrica. ,vol. 75, pp. 689- 695 ,(1986) , 10.1111/J.1651-2227.1986.TB10275.X