Pulmonary and vascular pharmacology of sphingosine 1-phosphate.
作者： V BRINKMANN , T BAUMRUKER
DOI: 10.1016/J.COPH.2005.12.004
关键词:
摘要: Dysregulation of vasomotor tone, endothelial barrier function and immune cell trafficking are central to the pathology many lung diseases, including acute injury, adult respiratory distress syndrome, chronic obstructive pulmonary disease asthma. There is increasing evidence that serum sphingolipid sphingosine 1-phosphate its G-protein-coupled receptors pivotal not only in regulation lymphocyte migration, but also maintenance vascular homeostasis preservation permeability barriers separate discrete compartments lung.
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