Mechanochemical synthesis of mesoporous tin oxide: a new generation nanosorbent for 68Ge/68Ga generator technology

摘要: The present article reports the synthesis and characterization of mesoporous tin oxide (MTO) nanoparticles by a solid-state mechanochemical route. synthesized material was used as an advanced sorbent for 68Ge/68Ga radionuclide generator technology. Gallium-68 (t½ = 68 min) obtained from is important diagnostic radioisotope which holds tremendous potential in non-invasive monitoring various diseases, including cancer, using positron emission tomography (PET). crystallite size MTO range 6–12 nm with large surface area 265 ± 16 m2 g−1, while mean pore radius found to be 2.1 0.6 nm. Determination zeta-potential dispersed solutions at different pH values aided understanding sorption separation mechanisms, were based on charge developed nanosorbent. capacity observed under column-flow conditions 85 5 mg Ge per g A clinical-scale (740 MBq) this could regularly eluted over prolonged period 1 year >70% elution yield met all requirements clinical use. suitability 68Ga it evaluated preclinical settings preparation 68Ga-labeled peptide containing arginine-glycine-aspartic acid (RGD) motif. To best our knowledge, first report route effectively utilized routine generators. promising results study would facilitate greater implementation mechanochemistry nanosorbents technology since method simple, economical convenient.