Restructuring reward processing with Mindfulness-Oriented Recovery Enhancement: novel therapeutic mechanisms to remediate hedonic dysregulation in addiction, stress, and pain

摘要: Though valuation processes are fundamental to survival of the human species, hedonic dysregulation is at root an array maladies, including addiction, stress, and chronic pain, as evidenced by allostatic shift in relative salience natural reward drug observed among persons with severe substance use disorders. To address this crucial problem, novel interventions needed restore regulatory gone awry exhibiting addictive behaviors. This article describes a theoretical rationale empirical evidence for effects one such new intervention, Mindfulness-Oriented Recovery Enhancement (MORE), on top-down bottom-up mechanisms implicated cognitive control regulation. MORE innovative distinct from extant mindfulness-based that it unites traditional mindfulness meditation reappraisal savoring strategies designed reverse downward reward, representing tipping point disrupt progression addiction-a mechanistic target no other behavioral intervention has been address. additional studies needed, clinical biobehavioral data several completed ongoing trials suggest may exert salutary behaviors neurobiological underpin them.