Evaluation of asymmetric immunoliposomal nanoparticles for cellular uptake.
作者： Jeremiah Whittenton , Ramanan Pitchumani , Sundararajah Thevananther , Kishore Mohanty
DOI: 10.3109/02652048.2012.696152
关键词:
摘要: Effective and targeted in vivo delivery of polynucleotide therapeutics is the key for treatment many diseases. Asymmetric immunoliposomes can be used as vehicles to deliver polynucleotides effectively because two leaflets bilayer have different compositions, which enhance capacity. The formation vitro cellular uptake asymmetric containing cargoes were studied here. Maleimide-functionalised DSPE-PEG (2000) incorporated into outer leaflet produce liposomes capable covalently attaching antibodies. Thiolated antibodies from both human rabbit origin conjugated pendant-type that retain their specificity towards detection through process. Human IgG-conjugated readily internalised (>20 per cell) by macrophage, HEPG2, CV-1 monkey kidney cells. cells liposomal nanoparticles endocyt...
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