Blast-induced hearing loss suppresses hippocampal neurogenesis and disrupts long term spatial memory

摘要: Acoustic information transduced by cochlear hair cells is continuously relayed from the auditory pathway to other sensory, motor, emotional and cognitive centers in central nervous system. Human epidemiological studies have suggested that hearing loss a risk factor for dementia decline, but mechanisms contributing these memory impairments are poorly understood. To explore issues controlled experimental setting, we exposed adult rats series of intense blast wave exposures significantly reduced neural output cochlea. Several weeks later, used Morris Water Maze test, hippocampal-dependent task, assess ability Blast Wave Control learn spatial navigation task (memory acquisition) remember what they had learned (spatial retention) several earlier. The elevated plus maze open field arena were test anxiety-like behaviors. Afterwards, hippocampal cell proliferation neurogenesis evaluated using bromodeoxyuridine (BrdU), doublecortin (DCX), Neuronal Nuclei (NeuN) immunolabeling. equally well showed no differences on tests anxiety. However, performed worse retention i.e., remembering where been two Deficits associated with significant decreases neurogenesis. Our results consistent manipulations link deficits (long term memory) decreased hippocampus. These add growing body knowledge linking blast-induced often seen combat personnel provide mechanistic insights into extra disorders could lead therapeutic interventions.