Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole
作者： Sara Braga Honorato , Jorge Souza Mendonça , Nubia Boechat , Alcemira Conceição Oliveira , Josué Mendes Filho
DOI: 10.1016/J.SAA.2013.08.096
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摘要: Abstract Benznidazole (N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide), is a nitro-heterocyclic drug used in the treatment of Chagas disease. Despite fact that this was released more than 30 years ago, little information about its solid state properties available literature. In study, it verified exhibits three polymorphs, which were characterized situ by X-ray powder diffraction, thermal analysis, hot stage microscopy and infrared spectroscopy. The thermodynamic relationships among these polymorphs also discussed.
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