Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study.

摘要: OBJECTIVE We aimed to study the effect of biosynthetic growth hormone (GH) replacement in deficient adults. DESIGN performed a double-blind placebo-controlled cross-over 6 months GH, and placebo separated by 1-month's washout period. PATIENTS Fourteen adults were studied. MEASUREMENTS measured total body weight, percentage fat mass, lean muscle volume, exercise capacity, maximum oxygen consumption, strength, bone mineral content, number biochemical parameters, IGF-I, GH antibodies psychological well-being. RESULTS Total weight remained unchanged, but mass increased (before mean +/- SEM 49.8 5.5, after 53.4 5.6 kg; before 51.2 5.4, 50.4 5.1 P less than 0.05 decreased 21.5 4.1, 19.3 4.3; 4.0, 22.5 4.5 0.05). Thigh volume increased: 94.1 7.7, 99.5 8.4 ml; 99.3 8.6, 95.4 7.8 ml/0.8 mm computerized tomographic slice; Exercise capacity 174 15, 199 18.9 watts; 162.5 2.3, 154 19.8 0.05), as did consumption 1.93 0.2, 2.17 0.2 l/m; 1.92 0.3, 1.98 There was no change quadriceps strength. Alkaline phosphatase 87.5 (32-158), 106.0 (49-179) U/I, (50-145), 72.0 (40-111) U/I; 0.05) without spinal density. IGF-I 62 (36-97), 216 (62-362) micrograms/l; 59 (52-112), 60.5 (38-94) Carbohydrate tolerance unchanged fasting lipids, serum sodium, potassium, urea, calcium, phosphate liver transaminases. Psychological well-being unchanged. No detected or treatment. CONCLUSIONS alters composition leads improved capacity; alkaline activity increases density, carbohydrate remains unaltered.