The Relevance of Vitamin D Receptor (VDR) Gene Polymorphisms for Cancer: A Review of the Literature

摘要: Background: In recent years, the relevance of vitamin D receptor (VDR) gene restriction fragment length polymorphisms for various types cancer has been investigated by a great number studies. It hypothesized that VDR may influence both risk occurrence and prognosis. However, studies investigating associations between specific often show controversial results. We have now performed systematic review literature to analyse individual malignancies, including skin, prostate, breast, colon, ovary, kidney bladder. Materials Methods: An analysis evaluating association Fok1, Bsm1, Taq1, Apa1, Cdx2, poly (A) Bgl1 as well some haplotype combinations performed. Data were extracted from PubMed using key words polymorphism in combination with breast cancer, prostate skin colorectal ovarian renal cell carcinoma or bladder cancer. Results: This was intent giving an up-to-date overview all data concerning Obviously, at present it is still not possible make any definitive statements about importance genotype occurrence. seems probable interactions other factors such calcium intake, 25(OH)D plasma levels UV radiation exposure play decisive role should be underestimated. Other obesity, smoking status, parity energy intake others are also frequently mentioned being more less important carcinogenesis depending on genotype. Moreover, noticed same different effect type only aggressive staging tumour. Conclusion: Significant reported (Fok1, (A)), A-1210), colorectum Bsm1), ovary Apa1) (Fok1), (Taq1, Apa1). conflicting most malignancies. After careful evaluation actual literature, can summarized indicating strongest (Bsm1, Fok1), (Fok1) malignant melanoma (MM) (Fok1). prognosis Taq1), MM (Bsm1) (Taq1).