Enantiospecific synthesis of (+)-(R)-1-phenyl-3-methyl-1,2,4,5-tetrahydrobenz[d]azepine from (+)-(S)-N-methyl-1-phenyl ethanolamine (halostachine) via arene chromium tricarbonyl methodology
作者： Steven J. Coote , Stephen G. Davies , David Middlemiss , Alan Naylor
DOI: 10.1016/S0040-4039(00)99447-4
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摘要: Abstract Acid promoted cyclisation of homochiral (R)-N-(3,4-dimethoxyphenethyl) halostachine chromium tricarbonyl is stereospecific, proceeding with retention configuration, to afford, after decomplexation, (+)-(R)-1-phenyl-3-methyl-1,2,4,5-tetrahydrobenz[d]azepine.
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