Reduction of serum melatonin levels in HIV-1-infected individuals' parallel disease progression: correlation with serum interleukin-12 levels.
作者： G. Nunnari , L. Nigro , F. Palermo , D. Leto , R. J. Pomerantz
DOI: 10.1007/S15010-003-4038-9
关键词:
摘要: During the natural history of human immunodeficiency virus type I (HIV-1) infection, an impairment interleukin-12 (IL-12) production precedes a switch from T-helper 1 (Th1) to a 2 (Th2) stage cellular immunity. Melatonin, the main hormone produced by pineal gland, seems to promote a Th1 response increasing IL-12 in vitro. The aim this study was measure and correlate serum levels melatonin and IL-12 in cohort HIV-1-infected individuals. 77 anti-HIV-1-positive subjects were enrolled: 20 in CDC A, 25 CDC B 32 C. 30 healthy HIV-1-seronegative recruited as controls. IL-12 and concentrations quantitated serum samples. Mean significantly lower in HIV-1-infected individuals comparison with controls (p < 0.001). Within HIV-1-seropositive group, mean patients CDC stage C, compared stages A < 0.01). HIV-1 disease, serum melatonin are progressively reduced. This reduction may be related Th1 immunoresponses.
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