Clinical Advances in Immunonutrition and Atherosclerosis: A Review

摘要: Atherosclerosis is a chronic low-grade inflammatory disease that affects large and medium-sized arteries considered to be major underlying cause of cardiovascular (CVD). The high risk mortality by atherosclerosis has led the development new strategies for prevention management, including immunonutrition. Plant-based dietary patterns, functional foods, supplements, bioactive compounds such as Mediterranean Diet, berries, polyunsaturated fatty acids, ω-3 ω-6, vitamins E, A, C, D, coenzyme Q10, well phytochemicals isoflavones, stilbenes, sterols have been associated with improvement in atheroma plaque at an level. However, many these correlations obtained vitro experimental animals' models. On one hand, present review focuses on evidence from epidemiological, intervention supplementation studies humans supporting role immunonutrient its effect anti-inflammatory response atherosclerotic disease. other this also analyzes possible molecular mechanisms protective action which may lead novel therapeutic approach prevent or attenuate diet-related disease, atherosclerosis.