Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials.

摘要: Abstract The majority of evidence suggests that n-6 polyunsaturated fatty acids, including linoleic acid (LA), reduce the risk cardiovascular disease as reflected by current dietary recommendations. However, concern has been expressed a high intake contributes to excess chronic inflammation, primarily prompting synthesis proinflammatory eicosanoids derived from arachidonic and/or inhibiting anti-inflammatory eicosapentaenoic docosahexaenoic acids. A systematic review randomized controlled trials permitted assessment LA on biologic markers inflammation among healthy noninfant populations was conducted examine this concern. search English- and non–English-language literature using MEDLINE, Cochrane Controlled Trials Register, EMBASE identify relevant articles. Fifteen studies (eight parallel seven crossover) met inclusion criteria. None reported significant findings for wide variety inflammatory markers, C-reactive protein, fibrinogen, plasminogen activator inhibitor type 1, cytokines, soluble vascular adhesion molecules, or tumor necrosis factor-α. only outcome measures higher intakes were greater excretion prostaglandin E2 lower 2,3-dinor-thromboxane B 2 in one study tetranorprostanedioic another. authors those both observed these effects not an indication increased inflammation. We conclude virtually no is available randomized, intervention healthy, human beings show addition diet increases concentration markers.