Effects of Taurine Supplementation on Mitochondrial Function in Chronic Ethanol Administered Rats

摘要: The present investigation was undertaken in vivo to determine whether the functional alterations of hepatic mitochondria induced by ethanol might be prevented taurine. We examined effects supplementation taurine on mitochondrial oxidative phosphorylation chronic ethanol-administered rates. Isolated from three groups rats were functionally tested an analysis β-hydroxbutyrate-supported respiration and coupling this process ATP synthesis presence ADP. control group(CO), ethanol(60g/L) administered group(AL), + taurine(5g/L) supplemented group(AT). Ethanol and/or given drinking water for 10 weeks. AL group had lower state 4 respiratory rate, control(RC) ratio ADP : O(P/O) those CO AT group. It showed that less coupled thus efficient with respect than both rats. suggests improve impaired efficiency dysfunction is recognized as a cause liver diseased consumption.