Hypochlorous Acid Activates Tyrosine Phosphorylation Signal Pathways Leading to Calcium Signaling and TNFαProduction
作者： Gary L. Schieven , Henry de Fex , Linda Stephenson
DOI: 10.1089/15230860260196308
关键词:
摘要: Hypochlorous acid is an important oxidizing agent produced by neutrophils to aid in defense against pathogens. Although hypochlorous known cause tissue damage due its cytotoxicity, the effect of this on signal transduction cells immune system and effects their responses are not well understood. In study, was found induce cellular tyrosine phosphorylation both T B lymphocytes, activate ZAP-70 kinase, calcium signaling a kinase-dependent manner. These events also occurred cell lines that did express T-cell receptor, indicating ability bypass normal receptor control. induced tumor necrosis factor-alpha production peripheral blood mononuclear results suggest may contribute inflammatory activating pathways system.
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