Foetal haemoglobin-blood cells (F-cells) as a feature of embryonic tumours (blastomas)

摘要: Tumour markers are important in the diagnosis and monitoring of many tumours. This study tested hypothesis that an oncofoetal protein, foetal haemoglobin (HbF) is a potential tumour marker embryonic tumours, useful for management. An immunohistochemical investigation HbF blood cell (Fc) distribution was carried out tumours bone marrow samples from 83 children 13 adults with various (blastomas), 24 leukaemia patients. In three, main blastoma types, nephroblastoma (Wilms' tumour), neuroblastoma retinoblastoma, where all patients, except two, were children, around 80% had Fc within proliferating vessels spaces between cells. parallel, clusters Fc, mostly F-erythroblasts (Feb), distributed some those patients 79% Foetal haemoglobin, as well being prognostic cancer marker, indicator DNA hypomethylation implicated development these others previously noted presence HbF.